BETA-BLOCKERS IN VENTRICULAR ARRHYTHMIAS: BEYOND RATE CONTROL - ANTIADRENERGIC EFFECTS IN ISCHEMIC AND NONISCHEMIC CARDIOMYOPATHY
- University of Health Sciences Antigua.
- Dow University of Health Sciences, karachi, Sindh, PK.
- Yangzhou Medical University.
- Al Nafees Medical College , Isra University , Islamabad Pakistan.
- Windsor University School of Medicine.
- Department of Medicine, Ghulam Muhammad Mahar Medical College, Sukkur, Pakistan .
- Louisiana State University in Shreveport , USA .
- Independent Researcher, Rochester New York. USA.
- Nanchang university china.
- Southwest Medical University , China .
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Abstract
Background:Ventricular arrhythmias (VAs) remain a leading cause of sudden cardiac death (SCD) in patients with ischemic and nonischemic cardiomyopathy, driven substantially by sympathetic nervous system overactivity and elevated catecholamine tone. Beta-adrenergic receptor blockers have been a cornerstone of pharmacotherapy for decades, yet their antiarrhythmic efficacy extends well beyond simple heart rate reduction.
Objective:This narrative review synthesizes current evidence on the antiadrenergic mechanisms by which beta-blockers suppress ventricular arrhythmogenesis, evaluates their clinical impact in ischemic and nonischemic cardiomyopathy populations, delineates differential effects among specific beta-blocker agents, and details their safety profiles and clinical limitations.
How to Cite This Article
Priyanka Hayre (2026); BETA-BLOCKERS IN VENTRICULAR ARRHYTHMIAS: BEYOND RATE CONTROL - ANTIADRENERGIC EFFECTS IN ISCHEMIC AND NONISCHEMIC CARDIOMYOPATHY, Jana Nexus: Journal of Health and Medicine, 2 (05), 10-21, ISSN (O) 3107-7889. DOI: https://doi.org/10.21474/JNHM01/130
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