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Background:Polymethyl methacrylate (PMMA) has long been the standard for denture base fabrication, but conventional heat- and cold-cured methods present drawbacks such as porosity, residual monomer release, and limited mechanical strength. Recently, UV-polymerized acrylic resins have emerged as a promising alternative. Objective:To review and synthesize current scientific data on the mechanical, thermal, chemical, and biological properties of UV-polymerized acrylic materials for denture bases and evaluate their clinical potential. Methods:A systematic literature review was conducted using Scopus, PubMed, ScienceDirect, and Google Scholar databases, focusing on articles published between 2014 and 2024. Forty-one studies were included, covering laboratory tests, clinical evaluations, and material technology assessments. Key parameters reviewed included flexural strength, surface hardness, porosity, residual monomer content, and biocompatibility. Results:UV-polymerized resins demonstrated improved flexural strength (120–140 MPa) and surface hardness (22–27 VHN) compared to traditional PMMA. SEM analysis showed smoother, less porous surfaces, aiding in microbial resistance and color stability. Residual monomer release was notably lower (?0.2%), and cytotoxicity was minimal. Thermal testing revealed dimensional changes below 0.4% After 500 cycles.These properties indicate enhanced safety and durability.